The present study comprised two parts. In the first part, authors attempted to work out the systematics of asthenic disorders based on our own observations of 189 children aged 7-14 years. The following clinical variants of asthenic states in children were singled out: cerebrogenic asthenia (14.3%), somatogenic (13.8%), residual (16.4%), dysontogenetic (20.1%) and neurasthenia (35.4%). In the second part, we summarized the results of treatment of neurasthenia with adaptol (32 patients) compared to pantoham (30 patients). The efficacy of adaptol was higher: the improvement was seen in 71.9% of cases compared to pantoham (56.7%). The good tolerability of adaptol which clinical efficacy is confirmed by neurophysiological and psychological studies is discussed.
Asthenia/classification , Asthenia/drug therapy , Biureas/therapeutic use , Neurasthenia/classification , Neurasthenia/drug therapy , Pantothenic Acid/analogs & derivatives , gamma-Aminobutyric Acid/analogs & derivatives , Adolescent , Asthenia/diagnosis , Biureas/adverse effects , Child , Humans , Neurasthenia/diagnosis , Pantothenic Acid/therapeutic use , Treatment Outcome , gamma-Aminobutyric Acid/therapeutic use
We examined 72 patients with headache of tension (HAT), 56 women and 16 men, aged from 18 to 45 years (mean age 32,7+/-8,5 years). Frequent HAT was diagnosed in 48 cases and chronic HAT - in 24 cases. Clinical-psychological and electroencephalographic study was conducted before and after the treatment with adaptol. The results were compared to those of the control group. This group included 30 patients treated with alprazolam. Two clinical variants of the disease were singled out: asthenic (25 patients) and anxiety (47 patients). The correctness of the identification was confirmed by electroencephalographic data. The higher efficacy of adaptol was noted in frequent HAT. During the treatment, there was the reduction of severity of cephalgia syndrome and of anxiety and asthenic scores as well, while depression scores did not change. Adaptol was more effective compared to alprazolam.
Anti-Anxiety Agents/therapeutic use , Headache/diagnosis , Headache/drug therapy , Stress, Psychological/complications , Adolescent , Adult , Alprazolam/therapeutic use , Electroencephalography , Female , Headache/etiology , Headache/psychology , Humans , Male , Middle Aged , Stress, Psychological/physiopathology , Young Adult
We examined 336 children, aged 7-14 years, with signs of school maladaptation (SM). Anxiety disorders were found in 167 (49.7%), including generalized anxiety disorder - 87 children (25.9%), phobic disorder - 40 children (11.3%), anxiety disorder - 14 (4.2%), social anxiety disorder - 26 (7.7%). These indices differed significantly from those in the comparison group of children without SM. The children with generalized anxiety disorder were treated with adaptol (1000 mg/d during 30 days). The clinical and psychological examination revealed the high efficacy of this drug. Adaptol was well-tolerated, with no side-effects observed.
Adaptation, Psychological/drug effects , Anti-Anxiety Agents/therapeutic use , Anxiety Disorders/drug therapy , Stress, Psychological/drug therapy , Adolescent , Child , Female , Humans , Male , Phobic Disorders/drug therapy
